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Cleavage by E. coli mismatch uracil-DNA glycosylase (MUG) of oligonucleotides containing several 5-substituted pyrimidine nucleotide residues. Lanes 15 show cleavage of a double-strand oligonucleotide with several 5-substituted pyrimidine nucleotide residues paired to the adenine base, and lanes 610 show the same sequence with the analogues paired to the guanine base. The oligonulcleotides (0.125 pmol/μl) were incubated with 4.0 units of MUG at 37°C for 60 minutes.
