Table III.
Markers of endocrine function by ovulatory status.
| Overalla | Ovulatory | Anovulatoryb | P-valuec | |
|---|---|---|---|---|
| n = 259 | n = 224 | n = 35 | ||
| Hirsutism score | 3.03 ± 2.58 | 3.01 ± 2.58 | 3.14 ± 2.66 | 0.78 |
| Currently have acne: n (%)d | 72 (30.5) | 58 (28.4) | 14 (43.8) | 0.08 |
| LH:FSH ratio | ||||
| Day 2 | 0.61 ± 0.44 | 0.61 (0.57, 0.65) | 0.87 (0.73, 1.02) | <0.01 |
| Day 7 | 0.71 ± 0.47 | 0.71 (0.67, 0.75) | 0.89 (0.76, 1.03) | 0.01 |
| Average of Day 2 and 7 | 0.70 ± 0.45 | 0.67 (0.64, 0.71) | 0.93 (0.80, 1.07) | <0.01 |
| SHBG (nmol/l): Day 2 | 44.50 ± 29.05 | 45.06 (42.54, 47.73) | 35.18 (30.33, 40.82) | <0.01 |
| Glucose (mg/dl): Day 2 | 87.00 + 7.00 | 87.31 (86.57, 88.05) | 86.39 (84.49, 88.30) | 0.38 |
| Insulin (uIU/ml): Day 2 | 6.00 + 4.50 | 5.79 (5.42, 6.18) | 6.89 (5.82, 8.15) | 0.06 |
| HOMA-IR: Day 2 | 1.32 + 0.56 | 1.29 (1.21, 1.38) | 1.48 (1.24, 1.76) | 0.17 |
ANOVA, analysis of variance; CI, confidence interval; HOMA-IR, homeostasis model assessment of insulin resistance; SHBG, sex hormone-binding globulin.
aValues are mean ± SD for overall population. Values for ovulatory and anovulatory women are predicted means (95% CI) after adjusting for age and BMI. LH:FSH ratio, SHBG, Insulin and HOMA-IR are geometric means.
bAt least one anovulatory cycle. Twenty-eight women in the study had only one anovulatory cycle, and seven women in the study had two anovulatory cycles. There were a total of 42 anovulatory cycles out of a total 509 in the BioCycle Study.
cP-value for continuous variables calculated using ANOVA, for acne calculated using a χ2 test.
dAcne: five or more pimples, pustules or nodules on the face (except nose) during the last 3 months.