Table 3.

Odds Ratios for Subjects With Alzheimer Disease vs Nondemented Subjects by Mediterranean Diet Score in Continuous and Tertile Form

Model	Nondemented, No.	AD, No.	MeDi Continuous OR (95% CI)	P Value	MeDi Tertiles OR (95% CI)		P for Trend
1*	1790	194	0.81 (0.74–0.88)	<.001	Low	1 (Reference)	<.001
					Middle	0.58 (0.42–0.81)
					High	0.40 (0.26–0.61)
2†	1300	137	0.76 (0.67–0.87)	<.001	Low	1 (Reference)	<.001
					Middle	0.47 (0.29–0.76)
					High	0.32 (0.17–0.59)
3‡	1259	135	0.76 (0.66–0.86)	<.001	Low	1 (Reference)	<.001
					Middle	0.48 (0.29–0.79)
					High	0.31 (0.16–0.58)

Abbreviations: AD, Alzheimer disease; CI, confidence interval; MeDi, Mediterranean diet; OR, odds ratio.

^*Model 1 is unadjusted.

^†Model 2 is adjusted for cohort, age, sex, ethnicity, education, apolipoprotein E genotype, caloric intake, smoking, comorbidity index, and body mass index (calculated as weight in kilograms divided by height in meters squared).

^‡Model 3 is adjusted for all variables of model 2 plus the following additional vascular variables: history of stroke, diabetes mellitus, hypertension, and heart disease and plasma levels of total cholesterol, high-density lipoprotein, triglycerides, and low-density lipoprotein.