Appendix.

Comparison of Frailty Components for Men in the Cardiovascular Health Study (CHS) and Men in the Outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study

Frailty Component	CHS Definition (n=2233)	MrOS Definition (n=3133)
Shrinking / weight loss	Self-report of >10 pounds lost unintentionally in previous year or documented unintentional weight loss of ≥5% in previous year	Documented unintentional weight loss of ≥5% between baseline and sleep exam (mean years between exams 3.4 ± 0.5)
Weakness	Lowest quintile in grip strength stratified by BMI quartiles:	Lowest quintile in grip strength stratified by BMI quartiles:
	Strength ≤29 for BMI ≤24.0	Strength ≤32 for BMI ≤24.5
	Strength ≤30 for BMI 24.1–26.0	Strength ≤34 for BMI 24.6–26.7
	Strength ≤30 for BMI 26.1–28.0	Strength ≤34 for BMI 26.8–29.4
	Strength ≤32 for BMI >28.0	Strength ≤34 for BMI >29.4
Poor energy	Positive answer to either of two statements from the CES-D Depression Scale: I felt that everything I did was an effort; (and) I could not get going	Negative response to the question from the GDS self-administered questionnaire: Do you feel full of energy?
Slowness	Lowest quintile of walking time stratified by median height from a 15 foot (4.57m) course	Lowest quintile of walking time stratified by median height from a 6 meter course
	Time ≥7 seconds for height ≤173cm	Walking speed ≤0.93 m/s or unable for height ≤174cm
	Time ≥6 seconds for height >173cm	Walking speed ≤1.00 m/s or unable for height >174cm
Low physical activity	Lowest quintile of kcal/wk based on short version of the MLTA questionnaire (cutpoint <383 kcal/wk)	Lowest quintile of PASE score* (cutpoint ≤85.4, range 0–486)

^*Higher scores indicate higher activity level

Abbreviations: BMI, body mass index; CES-D, Center for Epidemiologic Studies-Depression; GDS, Geriatric Depression Scale; MLTA, Minnesota Leisure Time Activity; PASE, Physical Activity Scale for the Elderly