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. Author manuscript; available in PMC: 2011 Jan 21.
Published in final edited form as: J Thorac Oncol. 2009 Jan;4(1):87–92. doi: 10.1097/JTO.0b013e3181915052

Table 1.

Effect of bortezomib on protein targets of relevance to lung cancer.16

Protein and effect of bortezomib Function of protein Protein role in lung cancer
p27kip1 stabilization Cell-cycle inhibition, apoptosis Tumor suppressor
p53 stabilization DNA damage repair, cell-cycle inhibition, apoptosis Tumor suppressor, therapy resistance
NF-κB downregulation Transcription factor, apoptosis suppressor Cell survival, therapy resistance
Bcl-2, Bcl-xL downregulation Anti-apoptosis Cell survival, therapy resistance
Bax stabilization Pro-apoptosis Promote apoptosis
Cyclin D, E, A stabilization Cell-cycle progression Oncogenic