Table 4.

Most common grade ≥3 hematologic and non-hematologic toxicities (N = 113).

	Total grade ≥ 3		Grade 3		Grade 4
Adverse event	N	%	N	%	N	%
Hematologic toxicities
Thrombocytopenia	71	63	30	27	41	36
Neutropenia	59	52	37	33	22	19
Anemia	15	13	13	12	2	2
Non-hematologic toxicities
Fatigue	15	13	12	11	3	3
ALT/AST	14	12	13	12	1	1
Neuropathy	5	4	3	3	2	2
Dehydration	5	4	5	4	–	–
Hypokalemia	4	4	3	3	1	1
Pneumonitis	4*	4	3	3	–	–
Anorexia	3	3	3	3	–	–
Diarrhea	3	3	3	3	–	–
Dyspnea	3	3	3	3	–	–
Hyponatremia	3	3	3	3	–	–
Hypotension	3	3	2	2	1	1
Lung infection	3	3	3	3	–	–
Nausea	3	3	3	3	–	–
Thrombosis/embolism	3	3	2	2	1	1

ALT, alanine aminotransferase; AST, aspartate aminotransferase.

^*Includes one grade 5 event.