Table 4.

Genetic distance to a new genotype network decreases with increasing penetrance

N	c	d	Spearman's ρ	p-value
8	0.4	0.25	-0.268	< 2.2 × 10-16
		0.125	-0.211	< 2.2 × 10-16
	0.3	0.25	-0.218	< 2.2 × 10-16
16	0.35	0.25	-0.293	< 2.2 × 10-16
	0.25	0.125	-0.263	< 2.2 × 10-16
		0.25	-0.306	< 2.2 × 10-16
20	0.3	0.25	-0.26	< 2.2 × 10-16
	0.2	0.1	-0.269	< 2.2 × 10-16
		0.25	-0.33	< 2.2 × 10-16
		0.5	-0.4	< 2.2 × 10-16
	0.1	0.25	-0.23	< 2.2 × 10-16

Data for each parameter combination is based on 10⁴ different circuits and on the non-parametric rank correlation coefficient Spearman's ρ [76].