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. 1973 Oct;52(10):2389–2397. doi: 10.1172/JCI107428

Cholesterol Metabolism in Human Obesity

Paul J Nestel 1, Paul H Schreibman 1, E H Ahrens Jr 1
PMCID: PMC302496  PMID: 4729038

Abstract

An experiment was undertaken to test whether in severe obesity cholesterol production rates obtained by isotope kinetic analysis (two-pool compartmental analysis) are comparable to those measured by chemical sterol balance techniques. Eight severely obese but normocholesterolemic patients were studied by the balance method, and five of these eight were studied by compartmental analysis. Cholesterol turnover was 10% higher by compartmental analysis.

In the entire group of eight patients cholesterol turnover was greater than twice that found previously in nonobese patients studied under similar conditions with bile acids and neutral sterols both participating in the increase. This increment was directly related to excess body fat and to adipose cellularity, with correlation co-efficients of 0.66 and 0.72, respectively. The amount of cholesterol in the slowly turning over pool B was related to degree of adiposity, but that in plasma and in pool A did not differ from values in nonobese patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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