Figure 2. Association signals and LD structure of loci associated with HDL traits.

Panel A: CETP (cholesterol ester transfer protein) gene; panel B: SGCD (sarcoglycan delta) gene; panel C: PLTP (phospholipid transer protein) gene; panel D: LIPC (hepatic lipase) gene; panel E: FBLN5 (fibulin-5) gene. In each panel, data in the upper part are –log transformed p-values from association analyses with HDL mean particle size and HDL cholesterol, adjusted for age, age² and gender (open circles: p>0.01, solid circles: p≤0.01; pval – p-value). The lower part shows linkage disequilibrium (LD) structure of genotyped SNPs in the GRAPHIC cohort (r²-based grey shading; white: no LD (r² = 0), black: complete LD (r² = 1)). For legibility, in panel D (LIPC) only SNPs with significant association with mean HDL particle size (p<0.05) were plotted.