Figure 13. Cerezyme treatment in mouse models of infection with Cn.
CBA/J mice (n = 10 per group) were infected with 5×105 Cn wild type H99 strain intranasally. Mice were treated with PBS, 20 U/kg or 40 U/kg of Cerezyme (Cz) immediately after the injection of fungal cells and every 2 days. The higher dose of Cz conveyed a protective effect to infected mice, showing a significant increase in survival (by Wilcoxon-Rank Sum test P<0.01, compared to PBS treated mice). The data are representative of two separate experiments.