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. 2011 Jan 21;6(1):e16306. doi: 10.1371/journal.pone.0016306

Figure 3. Effect of varying doses of curcumin and TT on Hp-viability and secreted-MMPs in Hp-infected mice.

Figure 3

Two weeks SS1 infected mice groups were treated with increasing doses of curcumin (25 mg/kg or 50 mg/kg) or TT (50% or 100% of human dose) for 7-days. Histographic representation of colonization of SS1 strain, obtained by quantitative culture, in mouse and the effect of varying doses of curcumin or TT thereon. Results of urease-test for the respective samples were stated (A). Test for the presence of Hp-specific genes UreB and NapA and mouse-specific GAPDH gene in the DNA isolated from the gastric tissues of mice (B). The activities of MMP-3 and gelatinases in the PBS extracts of respective mouse gastric tissues were analyzed by casein (C) and gelatin (D) zymography respectively. Histographic representations of caseinolytic (E) and gelatinolytic (F) activities from the above zymograms and three other representative zymograms from independent experiments. Error bars = ±SEM. *, p<0.001; ns, nonsignificant vs. appropriate control.