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. 2011 Jan 21;6(1):e16306. doi: 10.1371/journal.pone.0016306

Figure 6. Comparison between curcumin and TT in modulating altered levels of MMPs and TIMPs during Hp-infection.

Figure 6

Two weeks SS1 infected mice groups were treated with curcumin or TT for 7-days. The activities of MMP-3 and gelatinases in the PBS extracts of respective mouse gastric tissues were analyzed by casein (A) and gelatin (B) zymograms respectively. Histogram representing caseinolytic (C) and gelatinolytic (D) activities of the above zymograms and three other representative zymograms from independent experiments. Error bars = ±SEM. *, p<0.001; $, p<0.01; ns, nonsignificant vs. appropriate control. Western blot (E) analysis of protein expressions of MMP-3, -9, TIMP-1 and -3 in respective samples, GAPDH served as loading-control. RT-PCR (F) analysis of MMP-3, -9, TIMP-1 and -3 mRNA expressions in respective gastric tissues, GAPDH served as control.