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. 2011 Jan 21;6(1):e16449. doi: 10.1371/journal.pone.0016449

Table 2. Single locus analysis of SNPs investigated.

Gene Polymorphism MAFcontrols MAFcases P trend FPRP ORhet a ORhom a ORdom a Probb
ERCC2 Asp312Asn (rs1799793) 0.30 0.34 0.041 0.922 0.91 (0.60–1.42) 2.12 (1.12–4.01) 1.14 (0.72–1.62) 0.445
ERCC2 Lys751Gln (rs13181) 0.31 0.37 0.163 0.673 1.45 (0.92–2.01) 1.54 (0.88–2.67) 1.43 (0.91–2.10) 0.453
MSH2 -118T>C (rs2303425) 0.17 0.17 0.812 0.930 0.86 (0.67–1.43) 1.39 (0.57–4.05) 0.88 (0.67–1.58) 0.367
MSH2 IVS1+9G>C (rs2303426) 0.48 0.56 0.052 0.849 1.15 (0.73–1.79) 1.83 (1.13–3.14) 1.34 (0.89–2.18) 0.492
OGG1 Ser326Cys (rs1052133) 0.23 0.29 0.070 0.044 1.32 (0.91–1.90) 2.48 (1.13–5.42) 1.78 (1.22–2.63) 0.502
OGG1 IVS4-15C>G (rs2072668) 0.33 0.42 0.027 0.338 1.52 (1.01–2.29) 2.01 (1.22–3.58) 1.63 (1.14–2.43) 0.531
XRCC1 Arg194Trp (rs1799782) 0.11 0.12 0.618 0.933 0.94 (0.58–1.54) 1.68 (0.27–10.25) 0.92 (0.59–1.57) 0.390
XRCC1 Arg399Gln (rs25487) 0.44 0.32 <0.001 0.128 0.57 (0.37–0.87) 0.44 (0.22–0.76) 0.55 (0.35–0.86) 0.598
PTGS2 -1195G>A (rs689466) 0.13 0.23 <0.001 0.023 1.99 (1.17–3.40) 7.04 (2.23–22.19) 2.54 (1.55–4.16) 0.599
PTGS2 -765G>C (rs20417) 0.08 0.18 <0.001 0.056 1.91 (1.23–2.97) 2.74 (0.95–7.90) 1.99 (1.31–3.05) 0.612
PTGS2 Ex10+837T>C (rs5275) 0.39 0.42 0.334 0.692 1.40 (0.91–2.16) 1.34 (0.74–2.45) 1.39 (0.92–2.09) 0.408
TLR2 –196 to –74del 0.19 0.23 0.091 0.364 1.51 (1.02–2.24) 2.14 (0.56–8.11) 1.54 (1.05–2.26) 0.465
TLR4 Thr399Ile (rs4986791) 0.06 0.09 0.021 0.445 1.74 (0.96–3.16) 7.57 (0.83–69.28) 1.96 (1.11–3.49) 0.504
CASP8 -652 6N ins/del (rs3834129) 0.29 0.20 0.005 0.154 0.66 (0.44–0.98) 0.42 (0.20–0.89) 0.61 (0.42–0.88) 0.539
CASP8 IVS12-19G>A (rs3769818) 0.14 0.16 0.375 0.803 1.33 (0.87–2.02) 0.83 (0.18–3.89) 1.30 (0.86–1.96) 0.414
CASP8 Asp302His (rs1045485) 0.04 0.05 0.421 0.894 1.36 (0.70–2.64) 0.95 (0.06–15.5) 1.33 (0.69–2.56) 0.402
a

Adjusted for age and gender in logistic regression model, Significant values are denoted as bold.

FPRP, false-positive report probability based on ORdom (assuming prior probability of 0.05 and power to detect an OR of 2.0 or 0.5).

ORhet, odds ratio of heterozygote vs. common homozygote genotypes, ORhom, odds ratio of rare homozygote vs. common homozygote genotypes, ORdom, odds ratio of heterozygote+variant homozygote vs. common homozygote genotypes.

b

Probability of association in genomic control method (Minimum = 0.5).