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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Exp Parasitol. 2010 Nov 11;127(2):423–428. doi: 10.1016/j.exppara.2010.10.011

Fig. 1.

Fig. 1

QCN is a potent inhibitor of TbHK1. (A) Structures of myricetin and QCN. (B) QCN inhibits rTbHK1. Increasing amounts (0-100 μM) of QCN were incubated with rTbHK1 (160 ng/assay) for 10 min at RT and HK assays were performed as described in the Materials and Methods. Please note that due to the complex nature of the mode of inhibition, IC50 values were estimated assuming single site binding. (C) QCN is a mixed inhibitor of TbHK1 with respect to ATP. Michaelis-Menten plots of inhibition with different QCN concentrations in assays containing varied ATP amounts.