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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Brain Behav Immun. 2010 Oct 23;25(2):360–372. doi: 10.1016/j.bbi.2010.10.020

Figure 2. Colocalization of CXCR4-MOR and CX3CR1-MOR in hippocampus (HIP), cingulate cortex (Cg), and periaqueductal grey (PAG).

Figure 2

Fluorescent photomicrographs of MOR- with CXCR4- or CX3CR1- containing cells in coronal sections (30 µm) through the HIP CA1/2 and dentate gyrus (DG) (Aa, a’; Bb, b’), Cg (Cc, c’), and PAG (Dd, d’). In each brain region examined, the upper left panels show MOR-immunoreactivity (IR) in green, the upper right panels show CXCR4-IR or CX3CR1-IR in red, and the large panel illustrates the merge image with numerous colocalized cells (solid white arrows A–D). CX3CR1-IR was also single-labeled on cells morphologically similar to microglia (outlined white arrows, a’; c’; d’). Schematics from Paxinos and Watson (2005) are included to indicate the locations of the panels within their respective brain regions. Scale Bars: 50 µm.