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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Brain Behav Immun. 2010 Oct 23;25(2):360–372. doi: 10.1016/j.bbi.2010.10.020

Figure 5. CXCL12 blocks morphine-induced hyperpolarization and reduction of input resistance in PAG neurons.

Figure 5

Morphine (10 µM) hyperpolarizes PAG neurons (A, D) accompanied by a reduction of input resistance (A, E). CXCL12 (10 nM) has no effect on resting membrane potential or input resistance (B–E). Pretreatment with CXCL12 blocks morphine’s effect on resting membrane potential and input resistance (C–E). * indicates significant difference from the morphine group (p < 0.01) by post-hoc Dunn’s tests (E) or Student-Newman-Keuls tests (F). Group data are presented as mean ± SEM.