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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Brain Behav Immun. 2010 Oct 23;25(2):360–372. doi: 10.1016/j.bbi.2010.10.020

Figure 7. CX3CL1 exhibits an all-or-none effect on subsets of PAG neurons treated with morphine.

Figure 7

Pretreatment with CX3CL1 (10 nM) blocks morphine’s neurophysiological effects (hyperpolarization and reduction of input resistance) in 8/14 PAG neurons (A, B) but not in the other 6/14 PAG neurons (C, D), resulting in a blunting of morphine’s effect when data from all cells are combined (Figure 6E, F).

* indicates significant difference from the morphine group and # indicates significant difference from the MOR + CX3CL1 group by post-hoc Dunn’s tests (p < 0.05). Group data are presented as mean ± SEM.