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Cytotoxicity and topo II inhibitory activity of podophenazines 10 to 12
| Compound | IC50 (μM) | Fold-stimulation of protein-linked DNA breaks | ||
|---|---|---|---|---|
| KB | KB-7D | 50 μM | 100 μM | |
| 1 | 0.16 | 24 | 24.6 | 28.4 |
| 10 | 0.11 | 0.56 | 3.1 | 4.5 |
| 11 | 0.48 | 10.59 | 1 | 1 |
| 12 | 6.63 | ND | ND | ND |
ND: Not determined
