Table 2. Clinical Progression Events.

Enrollment				Event
Age (years)	WHO Stage	CD4 cells/μl (%)	HIV RNA copies/ml	WHO Stage 3 or 4 Event	Event Day*	Recent CD4 cells/μl (%)†
5	2	673 (15)#	21,053	Death (meningitis)	87	n/a
7	2	319 (15) #	286,069	Death (pneumonia)	231	681 (18)
5	3	752 (23)	290,476	Death (stroke)a	55	n/a
10	2	1206 (26)	80,712	Extra-Pulmonary TB	541	752 (18)
3	3	1044 (25)	434176	Malnutrition	644	960 (26)
9	2	507 (8) #	528,371	Malnutrition	280	500 (6)
6	1	1112 (42)	63,681	Oral candidiasis	80	n/a
7	2	443 (12) #	403,195	Persistent fevers	68	n/a
7	1	244 (29)	61,000	Persistent fevers	182	249 (18)
5	2	939 (25)	250,387	Pulmonary TB	7	n/a
1	1	1883 (28)	366,095	Pulmonary TB	4	n/a
5	1	1779 (28)	>750,000	Pulmonary TB	198	968 (28)
7	1	882 (22)	83,710	Pulmonary TB	264	750 (20)
5	2	1399 (36)	229,562	Pulmonary TB	143	1091 (35)
8	3	492 (16)	167,995	Recurrent Bacterial Pneumonia	196	423 (15)
6	3	798(20)	160,770	Recurrent Bacterial Pneumonia	31	n/a
5	1	610 (15) #	198,047	Recurrent bacterial Pneumonia	168	301 (12)
9	2	371 (26)	397,826	Recurrent Bacterial Pneumonia	198	334 (26)
3	1	1436 (29)	43,684	Recurrent bacterial Pneumonia	227	835 (15)
6	2	616 (26)	74,125	Recurrent Bacterial Pneumonia	222	570 (18)
8	2	376 (21)	>750000	Chronic lung diseaseb	570	248 (18)
6	2	285 (20)	88,302	Symptomatic LIP~	53	n/a
8	3	870(26)	32,481	Symptomatic LIP~	528	532 (23)
7	3	775 (13) #	434176	Symptomatic LIP~	30	n/a
6	1	803 (36)	49,543	Thrombocytopenia	252	814 (33)

^*Number of days from enrollment

^†Most recent laboratory evaluation prior to the event, all within 90 days

n/a: no additional laboratory evaluation before event

^{^}borderline CD4 that rose upon repeat testing

^aDied after acute onset of right arm pain, left sided weakness and dyspnea; no autopsy was performed

^bPersistent (>1 month) productive cough, with small cysts and/or persistent opacification on chest x-ray.

^~Lymphoid Interstitial Pneumonitis.

^#Per WHO and Ugandan guidelines, CD4 count is given preference over % in children over 5 years for ART initiation.