Table 3. Univariate and Multivariate Cox Proportional Hazard Ratio Modeling of Time to Progression.

	Univariate		Multivariate
Baseline Measure	HR* (95% CI)	p-value	HR* (95% CI)	p-value
CD4% (per 10% point decrease)	2.0 (1.8-2.2)	0.005	2.0 (1.8-2.1)	0.013
Log HIV RNA, copies/ml (per unit log increase)	2.4 (1.9-3.0)	0.002	1.8 (1.1-3.2)	0.034
% CD4 Cell Activation^ (per 10% increase)	1.6 (1.5-1.6)	0.05
% CD8 Cell Activation ^ (per 10% increase)	1.3 (1.3-1.3)	0.05
Hemoglobin < 9 g/dl	3.1 (1.9-4.3)	0.06
HIV RNA > 100,000 (c/ml)	2.0 (1.4-2.7)	0.04
CD4% < 25%	1.6 (0.9-2.3)	0.16
Male~	2.0 (1.3-2.6)	0.04
Z-Score Weight-for-Age	0.9 (0.6-1.1)	0.21
Age (per year increase)	0.9 (0.7-1.0)	0.09
Age < 3	3.7 (1.7-8.0)	0.001	3.0 (1.3-7.0)	0.008
CD4 count (cells/μl,, per 100 cell increase)	1.0 (1.0-1.0)	0.53

^*Hazard Ratio

^{^}% of cells expressing both CD38+HLADR+

^~did not remain significant when adjusted for HIV RNA.