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. 2010 Jul 23;22(1):55–64. doi: 10.1089/hum.2010.109

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Copyright 2011, Mary Ann Liebert, Inc.

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FIG. 5. — Quantitative in vivo and ex vivo biodistribution analysis demonstrating HA-SSTR2 expression by intrathoracic H460 tumors after in vivo infection with Ad-CMV-HA-hSSTR2. (A, B) In vivo and ex vivo biodistribution into tumors correlate. Correlation of in vivo %I.D./g of ¹¹¹In-octreotide uptake into tumors by planar and MR (A; n = 12) or SPECT and MR (B; n = 12) correlated with %I.D./g assessed from excised tumors. (C) In vivo and ex vivo biodistribution analysis demonstrates increased uptake in tumors infected with Ad-CMV-HA-hSSTR2 compared with tumors infected with Ad-CMV-GFP. *Tumor infected with Ad-CMV-HA-hSSTR2 vs. tumors infected with Ad-CMV-GFP: p < 0.05, n = 6; error bars represent SD. (D, E) Immunohistochemistry directed at the HA-tag demonstrates expression of HA-SSTR2 in tumors infected with Ad-CMV-HA-hSSTR2 (arrow, E), but background activity in tumors infected with Ad-CMV-GFP (D).