Table 1.

Some unconventionally secreted proteins that have important implications in health and disease

Protein	Proposed secretion mechanism	References
FGF1	Non-vesicular	[57]
FGF2	Non-vesicular	[58]
Interleukin 1β	Vesicular	[59]
Galectins 1 and 3	Vesicular / Non-vesicular	[58,60]
HMGB1	Vesicular	[61]
AcbA	Vesicular	[25]
Thioredoxin	Non-vesicular	[62]
Engrailed Homeoproteins	Vesicular	[63]
HIV Tat	Non-vesicular	[64]
Tubby	Unclear	[65]
Yeast MATa	Non-vesicular	[4]