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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Mol Pharm. 2010 Sep 7;7(5):1388–1405. doi: 10.1021/mp100149j

Table 5.

Total volume, number and volume of liquid pockets, and proximity of capsules to liquid-filled regions in the fasted and fed small intestine (Reproduced from reference 72.). Fasting conditions and 1 hour after a meal (n=12)72.

Condition Fasted Fed
Total volume of liquid (mL) Mean±s.d 105±72a 54±41a
Range 45–319 20–156
Median 83 39
Individual (approx.)b 45, 48, 69, 73, 77, 81, 85, 94, 113, 115, 130, 319 20, 22, 26, 28, 30, 38, 44, 50, 70, 75, 101, 156
Number of liquid pockets Mean 4c 6c
Individual (approx.)b 2, 3, 4, 5, 8 2, 5, 6, 7, 11
Volume of liquid pocket (mL) Median 12d 4d
Number of capsules surrounded by liquid No./Total 14/28 1/5
Number of capsules partially surrounded by liquid No./Total 6/28 1/5
Number of capsules not in contact with liquid No./Total 8/28 3/5
a

P<0.01.

b

Approximate values read from graph.

c

P<0.05.

d

P<0.001