Fig. 5.

SLE-derived autoantibodies bind to cold-shock induced apoptotic cells and blebs. Cold-shock apoptotic cells and blebs were probed with SLE-derived autoantibodies (small upper-right panels; green) and DNA was stained with DAPI (small lower-right panels; blue). a Binding of the SLE-derived nucleosome-specific monoclonal autoantibody #32. b Binding of the SLE-derived monoclonal autoantibody KM-2 (recognizing the apoptosis-associated acetylation of histone H4 at K8, 12, 16). c Binding of plasma of diseased, 20-weeks-old, SLE (MRL/lpr) mice. Merge is indicated in the large left panels. Magnification ×40 (Color figure online)