Table 5.
Evidence for the 21 candidate genes at the Chr 10 locus
| Gene | Mb* | Gene expression difference MRL vs SM† Fold change (P value) |
Expression QTL analysis | Non-synonymous polymorphism |
||
|---|---|---|---|---|---|---|
| Female | Male | LOD score‡ | High allele | |||
| Btbd11 | 84.9 | −1.01 (0.940) | −1.21 (0.040) | - | - | - |
| Syn3 | 85.7 | +1.21 (0.003) | +1.03 (0.550) | - | - | - |
| Timp3 | 85.7 | −1.41 (0.004) | −1.25 (0.044) | 18.1 | SM | - |
| Stab2 | 86.3 | +1.12 (0.201) | +1.17 (0.082) | 53.2 | MRL | - |
| 1700113H08Rik | 86.6 | +1.15 (0.437) | −1.15 (0.439) | - | - | - |
| Ascl1 | 86.9 | +1.17 (0.089) | −1.06 (0.508) | - | - | - |
| Pah | 87.0 | −1.09 (0.001) | −1.19 (0.056) | 6.8 | SM | - |
| Igf1 | 87.3 | +1.39 (0.002) | +1.19 (0.072) | - | - | - |
| Pmch | 87.5 | +1.16 (0.151) | +1.00 (0.962) | - | - | - |
| 4930547N16Rik | 87.5 | −1.04 (0.538) | −1.08 (0.229) | - | - | E152A |
| Nup37 | 87.6 | −1.17 (0.007) | +1.03 (0.543) | - | - | - |
| Ccdc53 | 87.6 | −1.05 (0.567) | +1.14 (0.188) | - | - | - |
| Spic | 88.1 | −1.07 (0.581) | +1.11 (0.410) | - | - | - |
| EG237433 | 88.1 | +1.07 (0.583) | −1.15 (0.280) | - | - | - |
| Arl1 | 88.1 | +1.02 (0.723) | −1.13 (0.052) | - | - | - |
| Utp20 | 88.2 | −1.22 (0.032) | +1.10 (0.275) | - | - | - |
| Slc5a8 | 88.3 | +1.10 (0.110) | −1.18 (0.016) | - | - | - |
| Tmem16d | 88.5 | +1.13 (0.125) | +1.02 (0.760) | - | - | - |
| Gas2l3 | 88.8 | +1.03 (0.665) | +1.21 (0.665) | - | - | - |
| Nr1h4 | 88.9 | −1.19 (0.005) | +1.10 (0.085) | - | - | E28D, K199R |
| Slc17a8 | 89.0 | −2.52 (<0.001) | −2.11 (<0.001) | 50.4 | SM | - |
*
Build 37.
†
Fold changes are given as MRL mice compared to SM mice in males and females separately. P values were calculated by ANOVA analysis and are indicated in parentheses for the transcripts. Some of the genes have more than one transcript. We report here the most significant transcript. All other transcripts are indicated in Table S6, Supporting Information. Numbers in bold indicate significant difference between MRL and SM (P < 0.05).
‡
Results from QTL analysis for Chr 10 using the expression level of the transcript as the phenotype. The LOD score of the Chr 10 peak is indicated.