Table 2.
Concentrations (median (5 – 95 percentile)) of indices for vitamin B2, B6, and B12 by demographic and lifestyle characteristics in control cohort members (n=2319)
| Vitamin B2 indices | Vitamin B6 indices | Vitamin B12 indices | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Vitamin B2 sum (nmol/L) |
Riboflavin (nmol/L) |
FMN (nmol/L) |
Vitamin B6 sum (nmol/L) |
PLP (nmol/L) |
PL (nmol/L) |
PA (nmol/L) |
Cobalamin (pmol/L) |
MMA (μmol/L) |
||
|
|
|
|
|||||||||
| Sex | Male | 1105 | 19.2 (9.5; 71.3) |
13.4 (5.6 - 58.9) |
5.3 (2.2 - 17.9) |
69.5 (33.5; 190.5) |
35.6 (15.1 - 97.4) |
13.8 (6.8 - 36.1) |
18.4 (8.5 - 56.5) |
274 (154 – 467) |
0.17 (0.12 - 0.32) |
| Female | 1213 | 21.8 (10.9; 77.0) |
16.2 (6.9 - 64.5) |
5.4 (2.0 - 15.7) |
60.5 (31.1; 288.5) |
31.2 (13.4 - 130.0) |
13.1 (6.6 - 58.1) |
15.2 (7.3 – 106) |
303 (170 – 517) |
0.17 (0.11 - 0.31) |
|
| Pdifference† | <0.001 | <0.001 | 0.60 | <0.001 | <0.001 | 0.10 | <0.001 | <0.001 | 0.49 | ||
| Age | < 60 | 1274 | 20.0 (9.8; 73.3) |
13.8 (5.9 - 58.9) |
5.7 (2.2 - 16.4) |
62.9 (32.1; 217.8) |
33.9 (14.7 - 115.0) |
12.8 (6.5 - 41.9) |
15.6 (7.5 - 67.0) |
294 (167 – 488) |
0.16 (0.11 - 0.27) |
| ≥ 60 | 1044 | 21.4 (10.4; 74.7) |
15.9 (6.8 - 64.2) |
4.9 (2.0 - 15.8) |
66.2 (32.1; 228.2) |
32.8 (13.8 - 105.0) |
13.9 (6.9 - 45.9) |
17.7 (8.3 - 81.8) |
279 (153 – 506) |
0.18 (0.12 - 0.35) |
|
| Pdifference† | <0.005 | <.001 | <0.001 | 0.21 | 0.02 | <0.005 | <0.001 | <0.005 | <0.001 | ||
| Region* | North | 731 | 23.4 (12.3; 83.1) |
16.6 (6.8 - 64.2) |
6.5 (3.1 - 16.3) |
75.0 (34.0/ 328.6) |
36.9 (14.3 - 141.5) |
16.2 (6.5 - 76.0) |
21.1 (8.9 - 125) |
290 (166 - 478) |
0.17 (0.12 - 0.31) |
| Central | 999 | 21.5 (10.8; 80.9) |
16.0 (7.4 - 66.2) |
4.8 (1.9 - 16.5) |
65.4 (32.4; 211.3) |
33.0 (14.8 - 110.0) |
13.6 (7.3 - 37.1) |
16.3 (8.1 - 64.8) |
276 (161 – 481) |
0.18 (0.12 - 0.32) |
|
| South | 588 | 16.3 (8.1; 64.0) |
11.2 (4.8 - 51.5) |
4.9 (2.0 - 14.9) |
55.2 (28.6; 115.4) |
29.9 (13.3 - 73.2) |
11.0 (6.2 - 22.9) |
13.5 (6.5 - 29.6) |
304 (160 – 550) |
0.16 (0.11 - 0.31) |
|
| Pdifference‡ | <0.001 | <0.001 | <.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | ||
| Smoking | Never | 1024 | 21.8 (11.2; 83.4) |
16.3 (7.0 - 68.7) |
5.5 (2.1 - 16.5) |
65.4 (33.3; 225.9) |
34.2 (15.5 - 109.0) |
13.7 (7.2 - 47.0) |
16.5 (8.1 - 75.9) |
296 (166 – 503) |
0.17 (0.12 - 0.30) |
| Former | 774 | 21.0 (9.6; 87.7) |
15.0 (6.3 - 71.8) |
5.3 (2.1 - 16.8) |
69.1 (34.0; 216.1) |
35.1 (15.5 - 120.0) |
14.2 (7.1 - 40.1) |
18.2 (8.5 - 71.0) |
283 (161 – 498) |
0.17 (0.12 - 0.32) |
|
| Current | 507 | 18.4 (9.5; 57.8) |
12.3 (5.1 - 47.0) |
5.4 (2.1 - 14.2) |
57 (26.5; 220.6) |
28.9 (11.8 - 105.0) |
11.9 (5.4 - 41.6) |
14.7 (6.6 - 64.9) |
277 (147 – 482) |
0.16 (0.11 - 0.33) |
|
| Ptrend§ | <0.005 | <0.005 | 0.22 | 0.91 | 0.05 | 0.76 | 0.78 | <0.005 | 0.91 | ||
| Alcohol | abstainer | 166 | 19.3 (8.9; 87.6) |
14.3 (5.7; 65.3) |
5.0 (2.2; 15.0) |
59.4 (25.7; 228.2) |
29.5 (12.2; 120.0) |
13.2 (5.2; 54.8) |
16.7 (6.8; 83.5) |
321 (183; 527) |
0.16 (0.11; 0.32) |
| (grams/day) | 1- 30 | 1784 | 21.0 (10.4; 73.3) |
15.3 (6.5; 62.6) |
5.3 (2.0; 15.8) |
63.4 (32.0; 227.9) |
32.2 (14.3; 109.0) |
13.2 (6.6; 44.7) |
16.3 (7.8; 74.3) |
287 (161; 496)0 |
0.17 (0.12; 0.32) |
| ≥ 30 | 372 | 19.4 (9.4; 76.2) |
12.7 (5.4; 53.7) |
6.0 (2.3; 21.4) |
75.5 (35.2; 207.7) |
41.7 (16.4; 116.0) |
14.8 (7.7; 38.4) |
19.2 (8.1; 57.3) |
280 (162; 481) |
0.16 (0.11; 0.28) |
|
| Pdifference† | 0.03 | <0.001 | <0.005 | <0.001 | <0.001 | <0.001 | 0.001 | <0.005 | <0.005 | ||
*
North: Sweden and Denmark; Central:United Kingdom
†
Pdifference (two-sided) calculated by Mann Whitney U test; abstainers were excluded from statistical analyses on alcohol consumption
‡
Pdifference (two-sided) calculated by Kruskall Wallis test
§
Ptrend (two-sided) calculated by regression models