Table 4.
Adjusted relative risks (95% CI)* for colorectal cancer by quintiles† of indices for vitamins B2, B6, and B12 status by alcohol consumption and sex
| Alcohol | N cases/ controls |
Q1 | Q2 | Q3 | Q4 | Q5 | Ptrend‡ | Pinteraction§ | Pinteraction|| | |
|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||||
| Vitamin B2 sum | ||||||||||
| Overall | Abstainer | 83/ 144 | 1 | 0.88 (0.30; 2.54) |
1.51 (0.48; 4.72) |
1.01 (0.31; 3.23) |
1.06 (0.31; 3.72) |
0.82 | ||
| 1-30 g/d | 939/ 1671 | 1 | 0.83 (0.63; 1.09) |
0.92 (0.70; 1.20) |
0.85 (0.65; 1.12) |
0.83 (0.63; 1.09) |
0.27 | |||
| ≥ 30 g/d | 274/ 360 | 1 | 0.55 (0.33; 0.92) |
0.65 (0.39; 1.10) |
0.60 (0.34; 1.04) |
0.56 (0.32; 0.98) |
0.07 | 0.21 | ||
| Males | 1-30 g/d | 386/ 700 | 1 | 0.80 (0.53; 1.22) |
1.23 (0.82; 1.85) |
1.16 (0.76; 1.76) |
0.87 (0.56; 1.35) |
0.82 | ||
| ≥ 30 g/d | 220/ 285 | 1 | 0.50 (0.28; 0.89) |
0.66 (0.37; 1.19) |
0.76 (0.41; 1.40) |
0.50 (0.26; 0.96) |
0.15 | 0.14 | ||
| Females | 1-30 g/d | 553/ 971 | 1 | 0.84 (0.58; 1.20) |
0.75 (0.52; 1.08) |
0.69 (0.48; 0.99) |
0.80 (0.57; 1.14) |
0.17 | 0.27 | |
| ≥ 30 g/d | 54/ 75 | 1 | 0.58 (0.14; 2.40) |
0.53 (0.14; 1.94) |
0.20 (0.04; 0.99) |
0.52 (0.15; 1.80) |
0.22 | 0.55 | 0.91 | |
| Vitamin B6 sum | ||||||||||
| Overall | Abstainer | 86/ 149 | 1 | 0.53 (0.20; 1.41) |
0.73 (0.27; 1.96) |
1.04 (0.39; 2.80) |
0.39 (0.11; 1.39) |
0.54 | ||
| 1-30 g/d | 940/ 1691 | 1 | 0.92 (0.71; 1.18) |
0.78 (0.60; 1.02) |
0.91 (0.70; 1.19) |
0.76 (0.58; 1.01) |
0.09 | |||
| ≥ 30 g/d | 272/ 357 | 1 | 0.94 (0.49; 1.80) |
0.91 (0.47; 1.76) |
0.70 (0.37; 1.35) |
0.55 (0.28; 1.07) |
0.03 | 0.12 | ||
| Males | 1-30 g/d | 392/ 718 | 1 | 1.18 (0.77; 1.80) |
0.80 (0.52; 1.23) |
1.17 (0.77; 1.77) |
0.80 (0.51; 1.26) |
0.44 | ||
| ≥ 30 g/d | 218/ 282 | 1 | 0.56 (0.25; 1.25) |
0.50 (0.22; 1.13) |
0.41 (0.19; 0.91) |
0.34 (0.15; 0.76) |
0.01 | 0.01 | ||
| Females | 1-30 g/d | 548/ 973 | 1 | 0.79 (0.58; 1.08) |
0.80 (0.57; 1.12) |
0.77 (0.54; 1.10) |
0.76 (0.53; 1.09) |
0.14 | 0.50 | |
| ≥ 30 g/d | 54/ 75 | 1 | 2.21 (0.52; 9.36) |
1.79 (0.40; 8.07) |
3.19 (0.67; 15.20) |
0.92 (0.19; 4.49) |
0.86 | 0.34 | 0.03 | |
| Cobalamin | ||||||||||
| Overall | Abstainer | 88/ 154 | 1 | 0.36 (0.12; 1.11) |
0.77 (0.27; 2.26) |
0.75 (0.28; 2.01) |
0.56 (0.21; 1.53) |
0.66 | ||
| 1-30 g/d | 959/ 1708 | 1 | 0.94 (0.73; 1.22) |
1.10 (0.86; 1.42) |
1.06 (0.82; 1.38) |
1.05 (0.80; 1.37) |
0.49 | |||
| ≥ 30 g/d | 275/ 363 | 1 | 0.76 (0.46; 1.26) |
0.68 (0.41; 1.15) |
1.00 (0.60; 1.68) |
0.93 (0.54; 1.60) |
0.91 | 0.76 | ||
| Males | 1-30 g/d | 401/ 722 | 1 | 0.97 (0.67; 1.41) |
1.27 (0.88; 1.83) |
1.11 (0.75; 1.66) |
1.07 (0.69; 1.65) |
0.48 | ||
| ≥ 30 g/d | 221/ 289 | 1 | 0.93 (0.53; 1.64) |
0.73 (0.41; 1.31) |
1.07 (0.59; 1.96) |
0.99 (0.53; 1.84) |
0.93 | 0.66 | ||
| Females | 1-30 g/d | 558/ 986 | 1 | 0.89 (0.62; 1.29) |
0.96 (0.68; 1.37) |
1.03 (0.73; 1.45) |
1.00 (0.71; 1.41) |
0.72 | 0.76 | |
| ≥ 30 g/d | 54/ 74 | 1 | 0.45 (0.11; 1.76) |
0.58 (0.14; 2.31) |
0.73 (0.22; 2.45) |
0.71 (0.19; 2.59) |
0.80 | 0.90 | 0.78 | |
| MMA | ||||||||||
| Overall | Abstainer | 88/ 155 | 1 | 1.16 (0.45; 2.96) |
1.97 (0.68; 5.73) |
0.92 (0.33; 2.59) |
1.20 (0.43; 3.36) |
0.93 | ||
| 1-30 g/d | 961/ 1714 | 1 | 1.07 (0.82; 1.40) |
1.10 (0.85; 1.43) |
1.17 (0.90; 1.53) |
0.91 (0.69; 1.21) |
0.80 | |||
| ≥ 30 g/d | 276/ 365 | 1 | 1.45 (0.88; 2.39) |
1.28 (0.75; 2.17) |
1.28 (0.76; 2.17) |
1.28 (0.73; 2.27) |
0.53 | 0.63 | ||
| Males | 1-30 g/d | 400/ 723 | 1 | 1.19 (0.79; 1.81) |
1.33 (0.88; 2.03) |
1.22 (0.80; 1.85) |
1.01 (0.66; 1.54) |
0.98 | ||
| ≥ 30 g/d | 222/ 290 | 1 | 1.62 (0.92; 2.84) |
1.56 (0.86; 2.84) |
1.49 (0.83; 2.69) |
1.51 (0.81; 2.83) |
0.24 | 0.40 | ||
| Females | 1-30 g/d | 561/ 991 | 1 | 1.01 (0.71; 1.43) |
0.98 (0.70; 1.37) |
1.19 (0.84; 1.68) |
0.86 (0.59; 1.24) |
0.80 | 0.98 | |
| ≥ 30 g/d | 54/ 75 | 1 | 1.30 (0.37; 4.61) |
0.58 (0.13; 2.52) |
0.87 (0.23; 3.28) |
0.72 (0.14; 3.67) |
0.52 | 0.32 | 0.31 | |
NOTE: Counts do not necessarily add to the total sum due to missing data.
lower quintile is reference category. All analyses are matched for age, sex, study center and date of blood collection and further adjusted for smoking status, education level, physical activity, fiber intake, intake of red and processed meat, alcohol consumption, and BMI.
The cut off values for the quintiles of vitamin B2 sum were 14.2, 18.1, 23.5, and 33.4 μmol/L; for the vitamin B6 sum they were 45.4, 57.7, 72.6, and 105.3 μmol/L; for vitamin B12 they were 220, 266, 312, and 380 pmol/L; and for MMA they were 0.14, 0.16, 0.18, and 0.22 μmol/L.
Ptrend (two-sided) in risk calculated with conditional logistic regression models with the covariates in the model using values for quintile categories as the quantitative score of exposure
Pinteraction (two-sided) of the vitamin – CRC association by alcohol consumption (abstainers excluded) for the overall model, and separately for males and females.
Pinteraction (two-sided) of the vitamin – CRC association by sex, separately for individuals with low alcohol consumption (abstainers excluded) and high alcohol consumption.