Table 5.

Distribution of genotypes by cancer site, and their associations with CRC risk

		CRC-ALL		COLON		RECTAL
SNP		N cases/ controls	OR (95% CI)	N cases/ controls	OR (95% CI)	N cases/ controls	OR (95% CI)
CBS 699	CC	583/1056	1	356/ 702	1	226/ 361	1
	CT	603/1040	1.04 (0.90; 1.21)	374/ 656	1.12 (0.94; 1.35)	230/ 389	0.93 (0.74; 1.18)
	TT	141/ 253	1.00 (0.79; 1.26)	83/ 148	1.11 (0.82; 1.50)	58/ 103	0.87 (0.60; 1.25)
	Ptrend		0.78		0.25		0.39
CBS ins	0 ins	1233/2150	1	761/ 1367	1	472/ 783	1
	1 ins	212/ 358	1.02 (0.85; 1.23)	137/ 231	1.04 (0.83; 1.31)	75/ 127	1.00 (0.73; 1.36)
	2 ins	9/ 18	0.89 (0.40; 2.00)	4/ 12	0.65 (0.21; 2.04)	5/ 6	1.29 (0.39; 4.34)
	Ptrend		0.89		0.96		0.87
TCN2 67	AA	1026/1789	1	622/ 1147	1	406/ 649	1
	AG	263/ 490	0.95 (0.80; 1.12)	162/ 312	0.98 (0.79; 1.21)	100/ 181	0.87 (0.66; 1.15)
	GG	19/18	0.87 (0.50; 1.53)	13/ 22	1.03 (0.51; 2.08)	5/ 16	0.54 (0.20; 1.51)
	Ptrend		0.42		0.88		0.15
TCN2 776	CC	415/ 749	1	253/ 482	1	162/ 273	1
	CG	648/1170	0.99 (0.85; 1.16)	401/ 762	0.99 (0.81; 1.20)	248/ 412	1.01 (0.78; 1.30)
	GG	266/ 435	1.10 (0.90; 1.33)	160/ 266	1.13 (0.88; 1.46)	105/ 169	1.04 (0.76; 1.43)
	Ptrend		0.45		0.42		0.81

^*wildtype is reference category.