Figure 1.

Immunohistochemical localization of Aβs in the cortex of double transgenic mice coexpressing mouse/human chimeric APP with the Swedish mutation and human presenilin-1 with deletion of exon 9. The coronal brain sections are 12 μm in thickness. Nuclei (blue) and Aβ (red) were stained with Hoechst 33258 and antihuman Aβ antibody, respectively. (a) low-magnification view; (b) high-magnification view. Bar = 20 μm in (a); 5 μm in (b). (Reproduced from [85] with permission).