. 2011 Jan 24;127(2):e423–e441. doi: 10.1542/peds.2009-2701

TABLE 2.

Pooled Summary Statistics: Comparison of RLCs and DCs

	RLCs	DCs	P
Mean mortality, %
HAART-naive	7.6 (0 to 18.8)^a ± <0.1^b (8937)	1.6 (0 to 3.8)^a ± <0.1^b (1241)	<.001
Ref No.	¹²^,¹³^,¹⁶^,¹⁹^,²²^–²⁵^,²⁷^,²⁸^,³¹^,³³^,³⁵^,⁴²^,⁴⁴^,⁴⁵^,⁴⁷^,⁵¹, and ⁵²	⁵⁹^,⁶¹^,⁶⁹^,⁷¹^,⁷³^,⁷⁹, and ⁸²
All studies^c	7.5 (0 to 18.8)^a ± <0.1^b (9663)	1.7 (0 to 3.8)^a ± <0.1^b (1277)	<.001
Ref No.	Additionally ²¹^,²⁶^,⁴⁶, and ⁴⁸	Additionally ⁷⁴
Mean DPCY
HAART-naive	8.0 (0 to 41.5)^a ± 4.1^b (8937)	0.9 (0 to 1.1)^a ± 1.2^b (1241)	<.001
Ref No.	¹²^,¹³^,¹⁶^,¹⁹^,²²^–²⁵^,²⁷^,²⁸^,³¹^,³³^,³⁵^–⁴²^,⁴⁴^,⁴⁵^,⁴⁷^,⁵¹, and ⁵²	⁵⁹^,⁶¹^,⁶⁹^,⁷¹^,⁷³^,⁷⁹, and ⁸²
All studies^c	7.7 (0 to 41.5)^a ± 3.8^b (9663)	1.0 (0 to 3.1)^a ± 1.2^b (1277)	<.001
Ref No.	Additionally ²¹^,²⁶^,⁴⁶, and ⁴⁸	Additionally ⁷⁴
Mean baseline CD4%
HAART-naive	12 (5 to 20)^a ± 0.1^b (8437)	23 (7 to 47)^a ± 0.2^b (647)	.01
Ref No.	¹²^,¹³^,¹⁹^,²²^,²⁵^,²⁷^,²⁹^,³²^,³³^,³⁵^–³⁷^,³⁹^,⁴¹^,⁴²^,⁴⁴^,⁴⁵^,⁴⁷, and ⁵⁰^–⁵²	¹¹^,⁵⁶^,⁵⁷^,⁵⁹^,⁶⁶^,⁶⁹^,⁷¹^,⁷³^,⁷⁸, and ⁸²
All studies^c	12 (5 to 20)^a ± 0.1^b (8666)	23 (7 to 47)^a ± 0.1^b (719)	.003
Ref No.	Additionally ²¹ and ²⁶	Additionally ⁶⁰ and ⁷⁴
Mean baseline VL, log₁₀ copies per mL
HAART-naive	5.5 (5.1 to 6.1)^a ± 2.7^b (1882)	4.7 (4.4 to 5.2)^a ± 2.2^b (647)	<.001
Ref No.	¹²^,¹⁹^,²³^,²⁵^,³⁴^–³⁷^,⁴¹^,⁴⁶A;, ⁵¹, and ⁵²	⁵⁶^,⁵⁷^,⁵⁹^,⁶⁶^,⁶⁷^,⁶⁹^,⁷¹^,⁷³^,⁷⁸, and ⁸²
All studies^c	5.5 (4.9 to 6.1)^a ± 2.7^b (1992)	4.7 (3.6 to 5.2)^a ± 2.0^b (752)	<.001
Ref No.	Additionally ²¹ and ⁴⁶B	Additionally ⁶⁰^,⁷⁰, and ⁷⁴
Mean baseline age, y
HAART-naive	5.4 (1.8 to 10.0)^a ± 4.0^b (9494)	6.5 (5.1 to 10.5)^a ± 3.4^b (575)	.1
Ref No.	¹²^,¹³^,¹⁹^,²²^–²⁵^,²⁷^,²⁹^,³¹^,³⁴^,³⁶^,³⁷^,³⁹^,⁴¹^,⁴²^,⁴⁴^,⁴⁵^,⁴⁶^,⁴⁷, and ⁵⁰^–⁵²	⁵⁶^,⁵⁷^,⁵⁹^,⁶⁷^,⁶⁹^,⁷¹^,⁷³^,⁷⁸, and ⁸²
All studies^c	5.7 (1.8 to 13.0)^a ± 3.8^b (10169)	6.7 (5.1 to 12.5)^a ± 2.9^b (680)	.2
Ref No.	Additionally ²¹^,²⁶^,⁴⁶B, and ⁴⁸	Additionally ⁶⁰^,⁷⁰, and ⁷⁴
Mean baseline WAZ
HAART-naive	−2.2 (−3.8 to −1.6)^a ± 2.1^b (5748)	−0.4 (−0.8 to −0.3)^a ± 0.1^b (180)	<.001
Ref No.	¹³^,¹⁹^,²³^,²⁷^,³⁰^,³³^,³⁶^,³⁷^,⁴⁰^,⁴²^,⁴⁴^,⁴⁶^,⁴⁹^,⁵³, and ⁵⁵	⁵⁶^,⁵⁹^,⁶⁵^,⁷¹, and ⁷⁷
All studies^c	−2.2 (−3.8 to −1.5)^a ± 2.0^b (6009)	−0.4 (−0.8 to −0.3)^a ± 0.1^b (180)	<.001
Ref No.	Additionally ²⁰^,²⁶, and ⁴⁶B	—

N is the total number of patients involved in the statistic. Ref 60 overlaps 2 patients with the Pediatric AIDS Clinical Trial Group 377.⁶⁷

Range.

95% confidence interval for weighted mean.

Includes HAART-experienced patients.