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. 2010 Dec 14;30(2):328–340. doi: 10.1038/emboj.2010.329

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Copyright © 2011, European Molecular Biology Organization

This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.

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One model explaining the role of transcription and centromere chromatin in kinetochore maintenance. (A) Following DNA replication, histone H3 (italic ‘3') is inserted in place of CENP-A (‘A'). (B) Transcription through the alphoid array results in methylation of H3 on lysines (4 and 36). (C) During mitotic exit, the ‘centrochromatin' environment, with CENP-A, H3K4me2 and H3K36me2 recruits HJURP, which inserts CENP-A in place of some of the H3 molecules, maintaining the identity of the centromeric chromatin in the course of ongoing cell divisions (D). We have shown that removal of H3K4me2 both lowers centromeric transcription and inhibits the targeting of HJURP to centromere chromatin. Nucleosome drawings by Graham T Johnson.