Skip to main content
. Author manuscript; available in PMC: 2011 Dec 28.
Published in final edited form as: Biochemistry. 2010 Dec 3;49(51):10881–10889. doi: 10.1021/bi1017655

Table 3.

Influence of Point Mutations in ApoE3 and ApoE4 on Binding to Lipoprotein Particles

ApoE variant Relative binding a
VLDL HDL3
apoE3
 WT 1.0 1.0
 K146E 2.1 ± 0.5 1.2 ± 0.3
 K146Q 2.6 ± 0.5 1.0 ± 0.2
 P267A 0.5 ± 0.1 0.5 ± 0.1
 G278P 0.7 ± 0.2 0.6 ± 0.2
apoE4
 WT 1.0 1.0
 E255A 0.4 ± 0.1 0.5 ± 0.1
 G278P 0.8 ± 0.1 0.6 ± 0.1
a

Fractional binding of the apoE variants was determined using a VLDL/HDL3 distribution assay under defined conditions (see Experimental Procedures) and is expressed relative to the value for the respective WT protein. The values are mean ± SEM.