Figure 3.
Reduction of Cyp18a1 activity results in a phenotype similar to the loss of β FTZ-F1 function. Both da>CYP18-RNAi and βFTZ-F117/Df animals show failure to displace the air bubble (white arrowheads) anteriorly during prepupal development and show defects in head eversion (yellow arrowhead in da>), resulting in microcephalic and cryptocephalic phenotypes, respectively (white arrows). The third leg pair (red arrows) is malformed in all animals that reach this stage. Dissected third legs from adults are shown. fe, femur; ti, tibia; ta, tarsus.