Table 1.

Yeast and fungal prions.

Prion	Protein	Normal protein function	Prion manifestation	Refs.
[URE3]	Ure2p	Nitrogen catabolism: In the presence of a rich N source, Ure2p binds the positive transcription factor Gln3p, keeping it in the cytoplasm.	Inappropriate derepression of enzymes and transporters for the utilization of poor nitrogen sources.	(Lacroute, 1971) (Wickner, 1994)(Turoscy & Cooper, 1987)
[PSI+]	Sup35p	Translation termination, mRNA turnover	Increased readthrough of translation termination codons	(Cox, 1965)(Wickner, 1994)
[PIN+]	Rnq1p	none known	Increased frequency of generation of [PSI+] and [URE3] prions.	(Derkatch, et al., 1997)(Sondheimer & Lindquist, 2000) (Derkatch, et al., 2001)
[β]	Prb1p	Vacuolar protease PrB; prion form is active PrB, not amyloid	Poor sporulation, poor survival in stationary phase	(Zubenko, et al., 1982)(Roberts & Wickner, 2003)
[SWI+]	Swi1p	subunit of SWI-SNF chromatin remodeling complex	Partially defective Swi1- phenotype such as poor growth on raffinose, galactose or glycerol	(Du, et al., 2008)
[MCA]	Mca1p	Metacaspase homolog. ?apoptosis?		(Nemecek, et al., 2009)
[OCT+]	Cyc8p	Transcription co-repressor	Derepressed invertase, Cyc2p, other proteins	(Patel, et al., 2009)
[MOT3]	Mot3p	Transcription repressor of genes derepressed under anaerobiasis	Derepression of "anaerobic genes".	(Alberti, et al., 2009)
[GAR]	Pma1p, Std1p	plasma membrane proton pump; glucose signalling	Resistance to glucose-repression	(Brown & Lindquist, 2009)
[Het-s]	HET-s	No known non-prion function	Prion form necessary for heterokaryon incompatibility	(Coustou, et al., 1997)