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. 2010 Nov 4;300(1):G99–G108. doi: 10.1152/ajpgi.00379.2010

Fig. 3.

Fig. 3.

Selective induction of COX-2 expression in the colonic SMC of obstructed colon. A: Western blot detection of COX-2 in the colonic muscularis externa in the oral (left) and aboral (right) segments. B: Western blot detection of COX-1 in the colonic muscularis externa in the oral (left) and aboral (right) segments. C: Western blot detection of COX-2 in the mucosa/submucosa in the oral (left) and aboral (right) segments. The Western blot results were representative of 3 or 4 independent experiments. D: immunohistochemical staining of COX-2 expression in the oral (a, c) and aboral (b, d) colon segments in sham control (a, b) and obstruction (c, d) for 3 days. Note that e and f are higher magnification views of the muscularis externa of oral segment from sham (e) and obstruction (f). CM, circular muscle; LM, longitudinal muscle; MP, myenteric plexus. Calibration bars represent 50 μm.