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Chemical hypoxia activates basolateral intermediate-conductance (IKCa) channels. A: representative recording showing channel activation by 100 μM dinitrophenol (DNP) and 5 mM deoxyglucose (DG) [command voltage = 100 mV; channel openings indicated by current transitions between closed channel current (C) and open state (O1)]. B: summary of effect of DNP and DG, and subsequent washout (Wash), on channel activity [channel open probability (NPo)] (n = 10, *P = 0.04 compared with control).
