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Chemical hypoxia increases paracellular conductance (GS). A: representative experiment showing increases in transepithelial voltage (VT) after nystain-induced apical membrane permeabilization in control and paired DNP-treated colon. B: plots of total tissue conductance (GT) against short-circuit current (Isc; corrected for tissue area) obtained from A, the y-intercepts providing estimates of GS. C: summary of effect of DNP on GS (n = 6 pairs of tissue, *P = 0.005 compared with control).
