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. 2010 Nov 4;300(1):G109–G119. doi: 10.1152/ajpgi.00145.2010

Table 2.

Effects of EtOH and NAC on growth, body composition, and UEC

Group BW at Euthansia, g Weight Gain, g/day Abdominal Fat, % BW Liver Weight, g Liver Weight/BW, % Mean UEC, mg/dl
Chow 565 ± 10a 1.65 ± 0.08a 2.14 ± 0.18a 17.14 ± 2.26a 3.00 ± 0.13b
Control 758 ± 11d 3.13 ± 0.08d 3.81 ± 0.25b 21.66 ± 3.47a,b 2.68 ± 0.04a
NAC 864 ± 15e 3.95 ± 0.09e 3.62 ± 0.46b 29.16 ± 6.91b 3.24 ± 0.34b
EtOH 623 ± 15b 2.10 ± 0.11b 3.24 ± 0.26b 26.25 ± 4.10b 4.08 ± 0.06c 196 ± 35
EtOH + NAC 689 ± 18c 2.61 ± 0.13c 3.51 ± 0.25b 31.71 ± 7.88b 4.25 ± 0.16c 173 ± 33

Data are means ± SE for 7–11 rats/group.

Chow, ad libitum chow-fed rats; Control, rats fed high-fat diets via total enteral nutrition; NAC, rats fed control diets supplemented with 1.7 g·kg−1·day−1 N-acetylcysteine; EtOH, rats fed isocaloric diets with ethanol (EtOH) at 12 g·kg−1·day−1; EtOH + NAC, rats fed EtOH diet +1.7 g·kg−1·day−1 NAC; see materials and methods. BW, body weight; UEC, urine ethanol concentration. Means without a common superscript letter are significantly different (P < 0.05) by 1-way ANOVA followed by Student-Newman-Keuls post hoc analysis.