Table 2.
Group | BW at Euthansia, g | Weight Gain, g/day | Abdominal Fat, % BW | Liver Weight, g | Liver Weight/BW, % | Mean UEC, mg/dl |
---|---|---|---|---|---|---|
Chow | 565 ± 10a | 1.65 ± 0.08a | 2.14 ± 0.18a | 17.14 ± 2.26a | 3.00 ± 0.13b | |
Control | 758 ± 11d | 3.13 ± 0.08d | 3.81 ± 0.25b | 21.66 ± 3.47a,b | 2.68 ± 0.04a | |
NAC | 864 ± 15e | 3.95 ± 0.09e | 3.62 ± 0.46b | 29.16 ± 6.91b | 3.24 ± 0.34b | |
EtOH | 623 ± 15b | 2.10 ± 0.11b | 3.24 ± 0.26b | 26.25 ± 4.10b | 4.08 ± 0.06c | 196 ± 35 |
EtOH + NAC | 689 ± 18c | 2.61 ± 0.13c | 3.51 ± 0.25b | 31.71 ± 7.88b | 4.25 ± 0.16c | 173 ± 33 |
Data are means ± SE for 7–11 rats/group.
Chow, ad libitum chow-fed rats; Control, rats fed high-fat diets via total enteral nutrition; NAC, rats fed control diets supplemented with 1.7 g·kg−1·day−1 N-acetylcysteine; EtOH, rats fed isocaloric diets with ethanol (EtOH) at 12 g·kg−1·day−1; EtOH + NAC, rats fed EtOH diet +1.7 g·kg−1·day−1 NAC; see materials and methods. BW, body weight; UEC, urine ethanol concentration. Means without a common superscript letter are significantly different (P < 0.05) by 1-way ANOVA followed by Student-Newman-Keuls post hoc analysis.