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. 2010 Oct 14;300(1):G21–G32. doi: 10.1152/ajpgi.00363.2010

Fig. 5.

Fig. 5.

Pie charts (A), representative traces (B–D, left), and the proposed neuronal circuits (B–D, right) in neurons in which perfusion with KYN decreased the firing rate of DMV neurons. A: perfusion with KYN decreased (or abolished) the firing frequency of DMV neurons (N = 25), and BIC had no additional effect on the firing frequency in majority of these neurons. B: the decrease in firing rate induced by KYN is likely due to antagonism of glutamatergic receptors located on the membrane of the DMV neuron. C: perfusion with BIC in the presence of KYN increased the firing rate of DMV neurons (N = 3). This response was likely due to BIC-mediated inhibition of a tonic GABAergic input onto DMV neurons. D: perfusion with BIC in the presence of KYN further decreased the firing rate of DMV neurons (N = 2), suggesting the presence of tonic GABAergic synapses impinging onto non-GABAergic neurons.