Table 3.

Studies of GABA pathology following repeated NMDAR blocker treatment

Ref.	Species	Drug	Treatment	Post- treatment interval	Methods	mPFC	Results HP	Other
[5]	Mouse	Ketamine	30 mg/kg, × 2 days	18 hours	IF (protein)	↓
[6]	Mouse	Ketamine	30 mg/kg, × 1 or 2 days	1, 3 or 10 days	IF (protein)	↓ (2 day) n.c. (1 day)
[35]	Mouse	PCP	10 mg/kg × 10 days	3 days	ISH (mRNA)	n.c.		↓ VLO
[1]	Rat	PCP	2 mg/kg b.i.d., × 7 days	42 days	IHC (protein)		↓ DG and CA2/3 n.c. CA1	↑ M2 and CG1 ↓ M1
[12]	Rat	PCP	2.58 mg/kg, × 5 days or alternate days for 1 month	3 days	ISH (mRNA)	n.c. (5 day) ↓ (1 month)
[36]	Rat	PCP	5 mg/kg × 5 days	3 days	ISH (mRNA)	↓	n.c.	↓ VLO
[28]	Rat	PCP	2.0 mg/kg b.i.d. × 7 days	42 days	IHC (protein)		↓
[23]	Rat	PCP	2.0 mg/kg b.i.d. × 7 days	42 days	IHC (protein)		↓
[22]	Rat	PCP	2 mg/kg b.i.d. × 7 days	24 hours, 7, 21 or 42 days	IHC (protein)		↓ (42 days only)
[25]	Rat	Ketamine	30 mg/kg × 5 days	14 days	IHC (protein)		↓
[33]	Rat	MK801	0.02 mg/kg × 21 days	24 hours	IHC (protein)	n.c. (cell density)
[10]	Rat	MK801	0.02 mg/kg × 21 days	24 hours	IHC (protein)	n.c.	↓
[29]	Monkey	PCP	0.3 mg/kg b.i.d. × 14 days	8 days	IHC (protein)	n.c. (cell density) ↓ (IR terminals)
‡	Mouse	PCP Ketamine	6 mg/kg × 5 days 30 mg/kg × 5 days	3 days	IHC (protein)	n.c.	n.c.
‡	Mouse	PCP Ketamine	1,3 or 6 mg/kg × 5 days 7.5,15,or 30 mg/kg × 5 days	3 days	WB (protein)		n.c.	n.c in frontal cortex
‡	Rat	Ketamine	30 mg/kg × 5 days	3 days	IHC (protein)	n.c.	n.c.
‡	Rat	Ketamine	30 mg/kg × 5 days	3 days	WB (protein)		n.c.	n.c in frontal cortex

Abbreviations and symbols: IF, immunofluorescence (mean fluorescence/cell); IHC, immunohistochemistry (IR cell density); ISH, in situ hybridization (densitometry); WB, Western Blot; HP, hippocampus; mPFC, medial prefrontal cortex; CG1, cingulate cortex; VLO, ventrolateral orbitofrontal cortex; M1, primary motor cortex; M2, secondary motor cortex; n.c. no change; ↓, decrease; ↑, increase;

^‡present studies