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Effects of ketoconazole on midazolam pharmacokinetics (AUC(ketoconazole)/AUC(control)) in humans and animal models.
| Intravenous administration | Oral administration | Reference | |
|---|---|---|---|
| Humans | 5 | 16 | (Tsunoda et al., 1999) |
| Rats | 2 | 5 | (Kotegawa et al., 2002) |
| Wild-type mice | n.a. | 3 | (Granvil et al., 2003) |
| Tg-CYP3A4 mice | n.a. | 8 | (Granvil et al., 2003) |
