Table 3.
Drug transporter genetically modified mouse models.
Gene | Category | Example applications | References |
---|---|---|---|
Mdr1a (Abcb1a) | Knockout | Drug absorption, distribution and elimination, including brain penetration | (Schinkel et al., 1994; Schinkel et al., 1995; Schinkel et al., 1996) |
Mdr1a/1b (Abcb1a/1b) | Knockout | Drug distribution | (Schinkel et al., 1997) |
Bsep (Abcb11) | Knockout | Bile acid distribution and excretion | (Wang et al., 2001; Wang et al., 2003) |
Mrp1 (Abcc1) | Knockout | Disposition of xenobiotic drugs and endogenous leukotrienes | (Wijnholds et al., 1997) (Lorico et al., 1997) |
Mrp2 (Abcc2) | Knockout | Glutathione excretion, bile flow and drug disposition | (Vlaming et al., 2006) (Chu et al., 2006) |
Mrp3 (Abcc3) | Knockout | Acetaminophen disposition; biliary excretion | (Belinsky et al., 2005) (Zelcer et al., 2006) |
Mrp4 (Abcc4) | Knockout | Drug resistance and brain penetration. | (Leggas et al., 2004) |
Bcrp1 (Abcg2) | Knockout | Drug absorption, distribution and elimination, including the secretion of compounds into milk | (Zhou et al., 2002) (Jonker et al., 2002) |
Ostα | Knockout | Bile acid disposition | (Rao et al., 2008) |
Pept2 (Slc15a2) | Knockout | Role of Pept2 in drug distribution and excretion | (Rubio-Aliaga et al., 2003) (Shen et al., 2003; Shen et al., 2007) |
Mate1 (Slc47a1) | Knockout | Renal secretion of metformin | (Tsuda et al., 2009) |
Oct1 (Slc22a1) | Knockout | Hepatic uptake and intestinal disposition of organic cation drugs | (Jonker et al., 2001) |
Oct2 (Slc22a2) Oct1/2 (Slc22a1/2) |
Knockout | Renal excretion of drugs | (Jonker et al., 2003) |
Oct3 (Slc22a3) | Knockout | Role of Oct3 in drug distribution | (Zwart et al., 2001) |
Oat1 (Slc22a6) | Knockout | Excretion of organic anions and drugs | (Eraly et al., 2006) |
Oat3 (Slc22a8) | Knockout | Uptake of organic anions and drugs | (Sweet et al., 2002) (Sykes et al., 2004) |
OATP1B1 (SLCO1B1) | Transgenic | Hepatic uptake of mitoxantrone | (van de Steeg et al., 2009) |
Oatp1b2 (Slco1b2) | Knockout | Drug disposition and hepatic uptake | (Zaher et al., 2008) (Lu et al., 2008) (Chen et al., 2008) |