Table 1.
Alternative splicing ratio changes in mutant strains
| Mutant | Genes with isoform | Human homolog | Mutation | References |
|---|---|---|---|---|
| Ratio changes >2-fold | ||||
| asd-1(yb978) | 3 | FOX1/2 | Missense mutation G140R | (17) |
| exc-7(ok370) | 0 | ELAV 4 | 1404-bp deletion | C. elegans Gene Knockout consortium |
| fox-1(e2643) | 30 | FOX1/2 | 1255-bp deletion | (27) |
| hrp-1(ok963) | 11 | hnRNP A1 | 843-bp deletion | C. elegans Gene Knockout consortium |
| hrpf-1(tm3406) | 1 | hnRNP F/H | 426-bp deletion | National BioResource Project, C. elegans |
| mec-8(e398) | 17 | RBPMS2 | Amber mutation Q177X | (39) |
| ptb-1(gk113) | 8 | PTB | 542-bp deletion | C. elegans Gene Knockout consortium |
| rsp-2(ok639) | 10 | SRSF4 (SRp75) | 984-bp deletion | C. elegans Gene Knockout consortium |
| rsp-5(ok324) | 13 | SRSF2 (SC35) | 1116-bp deletion | C. elegans Gene Knockout consortium |
| rsp-6(tm367) | 12 | SRSF3 (SRp20) | 395-bp deletion | National BioResource Project, C. elegans |
| sup-12(st89) | 20 | RBM24 | Missense mutation within RRM, G77E | (31) |
| sym-2(mn617) | 3 | hnRNP F/H | Missense mutation Y163N | (40) |
| unc-75(e950) | 0 | CUG-BP | 6900-bp deletion | (33) |
| hrpf-1; sym-2 | 17 | hnRNP F/H | 843-bp deletion and missense mutation | This work |
Microarray analysis of embryonic mRNA between indicated splicing factor mutant strains and N2. The number of genes on the microarray undergoing >2-fold changes in isoform ratios in the mutant strain are indicated. Human homologs of the genes are indicated, as well as the type of mutation in the C. elegans genome.