Table 3.
Developmental changes in splicing regulation in mec-8(e398) and sup-12(st89) mutant strains
| Embryos | Adults | ||
|---|---|---|---|
| Gene | Exon | mec-8 | mec-8 |
| Genes with high embryo regulation in mec-8 | |||
| rnp-6 | 6 | 1.5 | 0.91 |
| ZK1127.9 | 2 | 1.8 | 0.64 |
| Y55F3AM.3 | 3 | 2.1 | 0.35 |
| lin-10 | 6 | 1.5 | 0.02 |
| lat-1 | 3 | 1.9 | −0.44 |
| dct-17 | 11 | 1.7 | 0.00 |
| unc-53 | 17 | −2.2 | 0.32 |
| sox-2 | 2 | −1.8 | 0.32 |
| F55C12.1 | 2 | −1.7 | −0.46 |
| nlp-18 | 2 | −1.6 | 0.25 |
| Genes with high embryo regulation in sup-12 | |||
| F42G9.6 | 7 | −2.3 | −0.04 |
| phy-2 | 10 | −1.6 | −0.03 |
| gsy-1 | 5 | −1.6 | −0.26 |
| Genes with high adult regulation in mec-8 | |||
| unc-43 | 10 | −0.3 | 2.52 |
| ccch-1 | 3 | 0.3 | 2.35 |
| pqn-70 | 3 | −0.3 | 2.16 |
| ret-1 | 7 | −0.1 | 2.04 |
| gsy-1 | 5 | 0.9 | 2.02 |
| clp-1 | 4 | −0.1 | 1.67 |
| Y97E10AR.2 | 3 | 0.2 | 1.56 |
| nhx-5 | 17 | −1.0 | −1.52 |
| unc-2 | 18 | 0.7 | −1.57 |
| ketn-1 | 16 | 0.1 | −1.62 |
| gip-1 | 6 | 0.1 | −1.76 |
| F28E10.1 | 8 | 0.7 | −1.98 |
| hrpf-1 | 5 | 0.4 | −2.51 |
| unc-89 | 19 | 0.1 | −2.76 |
Splicing events with an isoform ratio ≥ 1.5 (log2) in at least one of the two stages (embryo or adults) for either mec-8 or sup-12. Note that for the sup-12 mutant strain adult RNA we could detect no isoform ratios >1.5 compared to N2 adults.