Figure 7.

Analyses of potential promoter regions in the PANK1 gene responsible for p53-dependent regulation. Gene structure of PANK1 from the RefSeq annotation is shown together with data from the UCSC Genome Browser. Signals from H3K4me3 (track 1) and H3K36me3 (track 2) ChIP-Seq analyses of HUVEC cells show putative promoter and transcribed regions. CpG islands are marked in green (track 3) and open chromatin in violet (track 4). Conserved p53-binding sites in the PANK1 gene are indicated as black bars (track 5) and two of them overlap with H3K4me3 (red box). RNA polymerase ChIP-Seq signals from HeLa and HCT116 cells are shown at the bottom (track 6). The genomic region harboring the functional PANK1 promoter is shaded in grey.