Table 2.

Results of stability study on SLNs of amikacin before and after freeze drying

SLNs form	Temp (°C)	Mean particle size (nm)							Mean zeta potential (mV)							Mean PDI
		Time (day)							Time (day)							Time (day)
		1	3	7	15	30	45	60	1	3	7	15	30	45	60	1	3	7	15	30	45	60
Primary dispersion of sLNs	4	150	269	309	372	430	540	690	+4	+3	0	+1	0	−2	−1	0.46	0.43	0.050	0.54	0.7	0.9	1.0
	25	150	350	400	560	590	750	980	+4	+1	0	0	−2	0	0	0.46	0.50	0.60	0.87	0.98	1.0	1.2
	40	150	400	450	538	678	856	996	+4	0	0	+1	0	+1	0	0.46	0.60	0.77	0.89	0.90	1.0	1.0
Freeze-dried sLNs	4	190	193	192	195	198	200	199	+13	+15	+14	+15	+15	+14	+13	0.35	0.43	0.40	0.35	0.45	0.48	0.39
	25	190	194	195	195	196	198	197	+13	+17	+18	+14	+16	+17	+18	0.36	0.43	0.39	0.49	0.43	0.50	0.49
	40	190	198	185	210	196	199	194	+13	+16	+15	+15	+13	+16	+15	0.36	0.45	0.37	0.46	0.43	0.55	0.41