Video 1.

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The 3-D projection of tumor oxygen tension on the z-axis, along with hemoglobin saturation and total hemoglobin on the color scale identical to that shown in Fig. 3 (blue = deoxygenated → red = oxygenated, with the intensity modulated by the total hemoglobin content making vessels appear brighter). This enables visualization of gradients in tissue oxygen tension in relation to vessel morphology and oxygenation. It can be seen that the tumor oxygen tension is highly heterogeneous and has a steep gradient dividing a relatively well-oxygenated region from a relatively hypoxic region. (QuickTime, 2.6 MB).