Table 3.

Pooled Standardized Incidence Ratios by Proband Characteristics (Age, Tumor Histology), Relative's Age at Diagnosis, and Relationship for Glioma and Any Malignancies in First-Degree Relatives, 1994–2006 (MDACC), 1991–2004 (UCSF), and 1958–1997 (Sweden)

	Glioma				Any Malignancy
	No. Observed	No. Expected	SIR	95% CI	No. Observed	No. Expected	SIR	95% CI
Proband's age, years
≤19
20–50	86	37.61	2.29	1.83, 2.82	2,103	2,025.63	1.04	0.99, 1.08
>50	85	40.68	2.09	1.67, 2.58	1,148	1,187.08	0.97	0.91, 1.02
Proband's histology
High grade	175	98.17	1.78	1.53, 2.07	2,343	2,254.14	1.04	1.00, 1.08
Low grade	81	46.44	1.74	1.39, 2.17	1,548	1,658.35	0.93	0.89, 0.98
Relative's age, years
<45	118	52.83	2.23	1.85, 2.67	862	521.68	1.65	1.54, 1.77
≥45	138	91.83	1.50	1.26, 1.78	3,029	3,382.06	0.90	0.86, 0.93
Relationship
First-degree relatives	256	145.02	1.77	1.56, 2.00	3,891	3,934.51	0.99	0.96, 1.02
Siblings	39	15.26	2.56	1.82, 3.49

Abbreviations: CI, confidence interval; MDACC, MD Anderson Cancer Center; SIR, standardized incidence ratio; UCSF, University of California, San Francisco.