Table 3.
Relations of Quintiles of Body Size and Composition Measures with Incident Ischemic Stroke Among Women in the Cardiovascular Health Study Sample, United States, 1989–2007
| Adipose Measure (Quintile Cutpoints) | Women | |||||
| Person-Years | No. of Strokes | HRa | 95% CI | HRb | 95% CI | |
| Body mass index, kg/m2 | ||||||
| Quintile 1 (<22.5) | 5,684 | 62 | 1.00 | Referent | 1.00 | Referent |
| Quintile 2 (22.5–24.7) | 6,081 | 56 | 0.91 | 0.63, 1.30 | 0.88 | 0.61, 1.27 |
| Quintile 3 (24.8–27.0) | 5,970 | 73 | 1.18 | 0.84, 1.66 | 1.19 | 0.84, 1.67 |
| Quintile 4 (27.1–30.3) | 6,135 | 56 | 0.89 | 0.62, 1.28 | 0.87 | 0.60, 1.26 |
| Quintile 5 (>30.3) | 5,724 | 62 | 1.09 | 0.76, 1.57 | 1.00 | 0.69, 1.46 |
| Ptrend | 0.71 | 0.99 | ||||
| Body mass index at age 50 years, kg/m2 | ||||||
| Quintile 1 (<21.7) | 6,032 | 63 | 1.00 | Referent | 1.00 | Referent |
| Quintile 2 (21.7–24.7) | 6,127 | 63 | 0.99 | 0.70, 1.41 | 1.03 | 0.73, 1.47 |
| Quintile 3 (24.8–27.0) | 6,146 | 56 | 0.85 | 0.59, 1.22 | 0.85 | 0.59, 1.22 |
| Quintile 4 (27.1–30.3) | 5,804 | 64 | 1.02 | 0.72, 1.45 | 0.99 | 0.70, 1.41 |
| Quintile 5 (>30.3) | 5,486 | 63 | 1.08 | 0.75, 1.54 | 0.98 | 0.68, 1.42 |
| Ptrend | 0.70 | 0.82 | ||||
| Fat mass, kg | ||||||
| Quintile 1 (<25.6) | 5,513 | 66 | 1.00 | Referent | 1.00 | Referent |
| Quintile 2 (25.6–30.8) | 5,984 | 62 | 0.98 | 0.69, 1.38 | 0.97 | 0.69, 1.38 |
| Quintile 3 (30.9–35.8) | 6,073 | 64 | 0.95 | 0.67, 1.35 | 0.95 | 0.67, 1.35 |
| Quintile 4 (35.9–42.5) | 6,091 | 65 | 1.02 | 0.72, 1.44 | 0.97 | 0.68, 1.38 |
| Quintile 5 (>42.5) | 5,933 | 52 | 0.86 | 0.59, 1.25 | 0.81 | 0.55, 1.19 |
| Ptrend | 0.56 | 0.36 | ||||
| Fat-free mass, kg | ||||||
| Quintile 1 (<29.1) | 5,722 | 61 | 1.00 | Referent | 1.00 | Referent |
| Quintile 2 (29.1–31.2) | 5,776 | 65 | 1.13 | 0.79, 1.60 | 1.16 | 0.81, 1.64 |
| Quintile 3 (31.3–33.3) | 6,180 | 61 | 1.03 | 0.72, 1.47 | 1.06 | 0.74, 1.52 |
| Quintile 4 (33.4–36.2) | 6,033 | 58 | 1.04 | 0.72, 1.49 | 1.05 | 0.73, 1.51 |
| Quintile 5 (>36.2) | 5,883 | 64 | 1.16 | 0.81, 1.66 | 1.19 | 0.83, 1.70 |
| Ptrend | 0.59 | 0.56 | ||||
| Waist circumference, cm | ||||||
| Quintile 1 (<79.0) | 6,267 | 65 | 1.00 | Referent | 1.00 | Referent |
| Quintile 2 (79.0–86.4) | 5,766 | 50 | 0.86 | 0.59, 1.24 | 0.86 | 0.59, 1.25 |
| Quintile 3 (86.5–93.9) | 5,978 | 64 | 1.02 | 0.72, 1.44 | 1.00 | 0.71, 1.42 |
| Quintile 4 (94.0–102.4) | 6,002 | 62 | 0.99 | 0.70, 1.40 | 0.97 | 0.68, 1.39 |
| Quintile 5 (>102.4) | 5,580 | 68 | 1.21 | 0.85, 1.71 | 1.13 | 0.79, 1.61 |
| Ptrend | 0.22 | 0.39 | ||||
| Hip circumference, cm | ||||||
| Quintile 1 (<94.0) | 6,339 | 77 | 1.00 | Referent | 1.00 | Referent |
| Quintile 2 (94.0–98.4) | 5,141 | 63 | 1.06 | 0.76, 1.49 | 1.06 | 0.76, 1.48 |
| Quintile 3 (98.5–102.9) | 6,310 | 57 | 0.82 | 0.58, 1.16 | 0.84 | 0.59, 1.19 |
| Quintile 4 (103.0–109.9) | 6,247 | 58 | 0.84 | 0.59, 1.18 | 0.83 | 0.59, 1.17 |
| Quintile 5 (>109.9) | 5,556 | 54 | 0.89 | 0.62, 1.27 | 0.83 | 0.58, 1.19 |
| Ptrend | 0.23 | 0.14 | ||||
| Waist/hip ratio | ||||||
| Quintile 1 (<0.81) | 6,390 | 49 | 1.00 | Referent | 1.00c | Referent |
| Quintile 2 (0.81–0.86) | 6,027 | 47 | 0.98 | 0.65, 1.46 | 0.96c | 0.65, 1.44 |
| Quintile 3 (0.87–0.91) | 5,761 | 82 | 1.73 | 1.21, 2.46 | 1.72c | 1.20, 2.45 |
| Quintile 4 (0.92–0.96) | 5,912 | 51 | 1.04 | 0.70, 1.54 | 1.02c | 0.69, 1.52 |
| Quintile 5 (>0.96) | 5,504 | 80 | 1.76 | 1.23, 2.52 | 1.71c | 1.19, 2.46 |
| Ptrend | 0.003 | 0.006 | ||||
| Waist/height ratio | ||||||
| Quintile 1 (<0.49) | 6,102 | 58 | 1.00 | Referent | 1.00 | Referent |
| Quintile 2 (0.49–0.54) | 6,165 | 50 | 0.84 | 0.57, 1.22 | 0.83 | 0.57, 1.21 |
| Quintile 3 (0.55–0.59) | 5,844 | 62 | 1.07 | 0.75, 1.53 | 1.06 | 0.74, 1.52 |
| Quintile 4 (0.60–0.65) | 6,002 | 70 | 1.17 | 0.83, 1.66 | 1.13 | 0.80, 1.61 |
| Quintile 5 (>0.65) | 5,480 | 69 | 1.25 | 0.88, 1.78 | 1.17 | 0.82, 1.68 |
| Ptrend | 0.06 | 0.14 | ||||
Abbreviations: CI, confidence interval; HR, hazard ratio.
Adjusted for age and race (black, nonblack).
Adjusted for age, race (black, nonblack), smoking status (never, former, current), physical activity, alcoholic drinks/week (0, <7, 7–13, ≥14), educational attainment (less than high school, high school graduate, college or higher), serum creatinine, and hormone replacement therapy.
After additional adjustment for potential mediators (systolic blood pressure, antihypertensive medication use, diabetes, prediabetes, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglycerides, use of aspirin, and high-sensitivity C-reactive protein), the corresponding effect estimates were as follows: quartile 2 vs. quartile 1 (HR = 0.93, 95% CI: 0.62, 1.40), quartile 3 vs. quartile 1 (HR = 1.61, 95% CI: 1.11, 2.32), quartile 4 vs. quartile 1 (HR = 0.95, 95% CI: 0.64, 1.42), and quartile 5 vs. quartile 1 (HR = 1.53, 95% CI: 1.05, 2.24); Ptrend = 0.057.