Table 4.

Relations of Quintiles of Body Size and Composition Measures with Incident Ischemic Stroke Among Men in the Cardiovascular Health Study Sample, United States, 1989–2007

Adipose Measure (Quintile Cutpoints)	Men
	Person-Years	No. of Strokes	HRa	95% CI	HRb	95% CI
Body mass index, kg/m2
Quintile 1 (<23.4)	3,109	39	1.00	Referent	1.00	Referent
Quintile 2 (23.4–25.2)	3,299	36	0.93	0.59, 1.46	0.93	0.59, 1.47
Quintile 3 (25.3–26.8)	3,390	35	0.87	0.55, 1.38	0.86	0.54, 1.37
Quintile 4 (26.9–29.1)	3,406	31	0.80	0.50, 1.28	0.78	0.48, 1.25
Quintile 5 (>29.1)	3,325	40	1.11	0.71, 1.73	1.09	0.69, 1.71
Ptrend			0.91		0.99
Body mass index at age 50 years, kg/m2
Quintile 1 (<23.4)	3,356	34	1.00	Referent	1.00	Referent
Quintile 2 (23.4–24.8)	3,406	37	1.08	0.68, 1.72	1.06	0.66, 1.69
Quintile 3 (24.9–26.2)	3,260	40	1.30	0.82, 2.05	1.30	0.82, 2.06
Quintile 4 (26.3–28.2)	3,411	32	0.96	0.59, 1.56	0.97	0.60, 1.58
Quintile 5 (>28.2)	3,097	38	1.29	0.81, 2.05	1.29	0.81, 2.07
Ptrend			0.45		0.43
Fat mass, kg
Quintile 1 (<23.1)	3,137	36	1.00	Referent	1.00	Referent
Quintile 2 (23.1–27.9)	3,396	35	0.99	0.62, 1.57	0.98	0.61, 1.57
Quintile 3 (28.0–32.0)	3,469	34	0.95	0.59, 1.51	0.94	0.58, 1.50
Quintile 4 (32.1–37.6)	3,358	33	1.02	0.63, 1.65	0.98	0.61, 1.59
Quintile 5 (>37.6)	3,168	43	1.44	0.92, 2.25	1.42	0.90, 2.23
Ptrend			0.14		0.18
Fat-free mass, kg
Quintile 1 (<32.6)	2,931	37	1.00	Referent	1.00	Referent
Quintile 2 (32.6–36.6)	3,278	35	0.92	0.58, 1.46	0.94	0.59, 1.49
Quintile 3 (36.7–39.9)	3,312	35	0.90	0.57, 1.43	0.93	0.58, 1.48
Quintile 4 (40.0–43.5)	3,523	41	1.09	0.69, 1.71	1.09	0.69, 1.73
Quintile 5 (>43.5)	3,484	33	0.87	0.54, 1.40	0.86	0.53, 1.39
Ptrend			0.86		0.80
Waist circumference, cm
Quintile 1 (<89.5)	3,349	42	1.00	Referent	1.00	Referent
Quintile 2 (89.5–94.4)	3,323	33	0.84	0.53, 1.32	0.83	0.53, 1.31
Quintile 3 (94.5–99.1)	3,277	40	1.06	0.69, 1.64	1.05	0.68, 1.62
Quintile 4 (99.2–104.9)	3,410	27	0.67	0.41, 1.09	0.66	0.40, 1.07
Quintile 5 (>104.9)	3,170	39	1.09	0.70, 1.69	1.05	0.67, 1.64
Ptrend			0.95		0.79
Hip circumference, cm
Quintile 1 (<95.0)	3,324	48	1.00	Referent	1.00	Referent
Quintile 2 (95.0–98.9)	3,780	33	0.62	0.40, 0.97	0.60	0.38, 0.93
Quintile 3 (99.0–101.9)	3,010	31	0.75	0.48, 1.18	0.72	0.46, 1.14
Quintile 4 (102.0–106.4)	3,325	32	0.74	0.47, 1.16	0.72	0.46, 1.13
Quintile 5 (>106.4)	3,090	37	0.89	0.58, 1.37	0.86	0.56, 1.33
Ptrend			0.80		0.73
Waist/hip ratio
Quintile 1 (<0.92)	3,432	34	1.00	Referent	1.00	Referent
Quintile 2 (0.92–0.95)	3,356	47	1.47	0.95, 2.29	1.46	0.94, 2.27
Quintile 3 (0.96–0.97)	3,297	29	0.89	0.54, 1.46	0.89	0.54, 1.46
Quintile 4 (0.98–1.00)	3,281	39	1.27	0.80, 2.01	1.25	0.79, 1.98
Quintile 5 (>1.00)	3,163	32	1.08	0.67, 1.76	1.02	0.63, 1.67
Ptrend			0.98		0.82
Waist/height ratio
Quintile 1 (<0.51)	3,310	41	1.00	Referent	1.00	Referent
Quintile 2 (0.51–0.54)	3,454	35	0.81	0.51, 1.27	0.80	0.51, 1.26
Quintile 3 (0.55–0.57)	3,336	39	0.93	0.60, 1.43	0.90	0.58, 1.41
Quintile 4 (0.58–0.61)	3,215	28	0.70	0.44, 1.14	0.69	0.42, 1.11
Quintile 5 (>0.61)	3,214	38	0.97	0.63, 1.51	0.94	0.60, 1.47
Ptrend			0.73		0.60

Abbreviations: CI, confidence interval; HR, hazard ratio.

^aAdjusted for age and race (black, nonblack).

^bAdjusted for age, race (black, nonblack), smoking status (never, former, current), physical activity, alcoholic drinks/week (0, <7, 7–13, ≥14), educational attainment (less than high school, high school graduate, college or higher), and serum creatinine.